COX-2-IN-1
COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.
Product Specifications
CAS Number
787623-48-7
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-_4-Sulfamylphenyl_-3-trifluoromethyl-5-_7-chloroindol-3-yl_-2-pyrazoline.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(N2N=C(C(F)(F)F)CC2C3=CNC4=C3C=CC=C4Cl)C=C1)(N)=O
Molecular Formula
C18H14ClF3N4O2S
Molecular Weight
442.84
References & Citations
[1]Reddy MV, et al. Design, synthesis, and biological evaluation of 1- (4-sulfamylphenyl) -3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorg Med Chem. 2008 Apr 1;16 (7) :3907-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
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