ONO4057
ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.
Product Specifications
CAS Number
[134578-96-4]
Product Name Alternative
ONO-LB457
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ONO4057.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC=C1OCCCCC(O)=O
Molecular Formula
C27H34O7
Molecular Weight
470.55
References & Citations
[1]Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44 (4) :261-75.|[2]Tanaka M, et al. Effect of leukotriene B (4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32 (7) :2340.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTB4
Available Sizes
Curated Selection
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