Benzquinamide

Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively.

Product Specifications

CAS Number

[63-12-7]

Product Name Alternative

P2647; BZQ; Benzoquinamide

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/P2647.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC

Molecular Formula

C22H32N2O5

Molecular Weight

404.50

References & Citations

[1]Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109 (28) : 11178-11183. doi: 10.1073/pnas.1204524109