4-Biphenylsulfonyl chloride

4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC[1].

Product Specifications

CAS Number

[1623-93-4]

UNSPSC

12352200

Hazard Statement

H314

Target

Drug Intermediate

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-biphenylsulfonyl-chloride.html

Purity

99.59

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClS(C1=CC=C(C2=CC=CC=C2)C=C1)(=O)=O

Molecular Formula

C12H9ClO2S

Molecular Weight

252.72

Precautions

H314

References & Citations

[1]Zagni C, et al. Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design. Eur J Med Chem. 2017 Dec 1;141:188-196.