Zatosetron (maleate)
Zatosetron maleate is a potent and selective 5HT3 receptor antagonist.
Product Specifications
CAS Number
123482-23-5
Product Name Alternative
LY 277359 maleate
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Zatosetron_maleate.html
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C\C(O)=O.O=C(C1=CC(Cl)=CC2=C1OC(C)(C)C2)N[C@H]3C[C@@H](CC4)N(C)[C@@H]4C3
Molecular Formula
C23H29ClN2O6
Molecular Weight
464.94
References & Citations
[1]Robertson DW, et al. Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships. J Med Chem. 1992 Jan 24;35 (2) :310-9.|[2]Rasmussen K, et al. The 5-HT3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons. Eur J Pharmacol. 1991 Nov 19; 205 (1) :113-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Lactoferrin
Available Sizes
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