Zatosetron (maleate)

Zatosetron maleate is a potent and selective 5HT3 receptor antagonist.

Product Specifications

CAS Number

[123482-23-5]

Product Name Alternative

LY 277359 maleate

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Zatosetron_maleate.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C\C(O)=O.O=C(C1=CC(Cl)=CC2=C1OC(C)(C)C2)N[C@H]3C[C@@H](CC4)N(C)[C@@H]4C3

Molecular Formula

C23H29ClN2O6

Molecular Weight

464.94

References & Citations

[1]Robertson DW, et al. Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships. J Med Chem. 1992 Jan 24;35 (2) :310-9.|[2]Rasmussen K, et al. The 5-HT3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons. Eur J Pharmacol. 1991 Nov 19; 205 (1) :113-6.