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McN5691

McN5691 is a voltage-sensitive calcium channel blocker.

Product Specifications

CAS Number

99254-95-2

Product Name Alternative

RWJ26240

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/McN5691.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C=CC(CCN(C)C(C)CCC(C=C(OC)C=C2)=C2C#CC3=CC=CC=C3)=C1

Molecular Formula

C30H35NO3

Molecular Weight

457.60

References & Citations

[1]Flaim SF, et al. Structurally novel antihypertensive compound, McN-5691, is a calcium channel blocker in vascular smooth muscle. J Pharmacol Exp Ther. 1991 Jan;256 (1) :279-88.|[2]Wu WN, et al. Excretion and metabolism of the antihypertensive agent, RWJ-26240 (McN-5691) in dogs. Drug Metab Dispos. 1998 Feb;26 (2) :115-25.|[3]Flaim SF, et al. Effects of the novel calcium channel blocker, McN-5691, on cardiocirculatory dynamics and cardiac output distribution in conscious spontaneously hypertensive rat. J Cardiovasc Pharmacol. 1988 Apr;11 (4) :489-500.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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