MEN11467

MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist.

Product Specifications

CAS Number

[214487-46-4]

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MEN11467.html

Solubility

10 mM in DMSO

Smiles

CC(C=C1)=CC=C1CC(N(C)[C@H](CC2=CC3=CC=CC=C3C=C2)C(N[C@H](CCCC4)[C@H]4NC(C5=CNC6=C5C=CC=C6)=O)=O)=O

Molecular Formula

C38H40N4O3

Molecular Weight

600.75

References & Citations

[1]Cirillo R, et al. Pharmacology of MEN 11467: a potent new selective and orally- effective peptidomimetic tachykinin NK (1) receptor antagonist. Neuropeptides. 2001 Jun-Aug;35 (3-4) :137-47.|[2]Khan S, et al. Effect of the long-acting tachykinin NK (1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132 (1) :189-96.|[3]Palma C, et al. Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft. Br J Cancer. 2000 Jan;82 (2) :480-7.