Sch412348

Sch412348 is a potent competitive antagonist of the human adenosine A2A receptor (Ki=0.6 nM) and has >1000-fold selectivity over all other adenosine receptors.

Product Specifications

CAS Number

[377727-26-9]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Sch412348.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(N(CCN2CCN(C3=CC=C(F)C=C3F)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN15

Molecular Formula

C22H21F2N9O

Molecular Weight

465.46

References & Citations

[1]Hodgson RA, et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2- (2-furanyl) -7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression. J Pharmacol Exp Ther. 2009 Jul;330 (1) :294-303.