A81988
A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.
Product Specifications
CAS Number
[141887-34-5]
Product Name Alternative
Abbott81988
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/A81988.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1N(CCC)CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O
Molecular Formula
C23H22N6O2
Molecular Weight
414.46
References & Citations
[1]Hancock AA, et al. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267 (1) :49-54.|[2]Madeddu P, et al. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B (2) receptor knockout mice. Hypertension. 2000 Jan;35 (1 Pt 2) :391-6.|[3]Madeddu P, et al. Circulation. 1997 Nov 18;96 (10) :3570-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-U00188/A81988-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-U00188/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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