A81988
Product Specifications
UNSPSC Description
A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.
Target Antigen
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/A81988.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1N(CCC)CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O
Molecular Weight
414.46
References & Citations
[1]Hancock AA, et al. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54.|[2]Madeddu P, et al. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice. Hypertension. 2000 Jan;35(1 Pt 2):391-6.|[3]Madeddu P, et al. Circulation. 1997 Nov 18;96(10):3570-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-U00188/A81988-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-U00188/
Clinical Information
No Development Reported
CAS Number
141887-34-5
Curated Selection
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