A81988

A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.

Product Specifications

CAS Number

[141887-34-5]

Product Name Alternative

Abbott81988

UNSPSC

12352005

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/A81988.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CN=C1N(CCC)CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)O

Molecular Formula

C23H22N6O2

Molecular Weight

414.46

References & Citations

[1]Hancock AA, et al. [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267 (1) :49-54.|[2]Madeddu P, et al. Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B (2) receptor knockout mice. Hypertension. 2000 Jan;35 (1 Pt 2) :391-6.|[3]Madeddu P, et al. Circulation. 1997 Nov 18;96 (10) :3570-8.