NCX1022

NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory agent for the treatment of skin inflammation.

Product Specifications

CAS Number

[571186-50-0]

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NCX1022.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2(O)C(COC(C3=CC=C(CON(=O)=O)C=C3)=O)=O)([H])[C@@]4([H])[C@]([C@@]5(C(CC4)=CC(CC5)=O)C)([H])[C@@H](O)C1

Molecular Formula

C29H35NO9

Molecular Weight

541.59

References & Citations

[1]Hyun E, et al. Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis. Br J Pharmacol. 2004 Nov;143 (5) :618-25.