SQ28603

SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP) .

Product Specifications

CAS Number

100845-83-8

Product Name Alternative

SQ28,603; Squibb 28603

UNSPSC

12352005

Target

Neprilysin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SQ28603.html

Solubility

10 mM in DMSO

Smiles

OC(CCNC(C(CS)CC1=CC=CC=C1)=O)=O

Molecular Formula

C13H17NO3S

Molecular Weight

267.34

References & Citations

[1]Seymour AA, et al. Antihypertensive and renal activity of SQ 28,603, an inhibitor of neutral endopeptidase. J Cardiovasc Pharmacol. 1991 Feb;17 (2) :296-304.|[2]Seymour AA, et al. Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can J Physiol Pharmacol. 1991 Oct;69 (10) :1609-17.