Bunaprolast
Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.
Product Specifications
CAS Number
99107-52-5
Product Name Alternative
U66858
UNSPSC
12352005
Target
Leukotriene Receptor; Lipoxygenase; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/U66858.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C=CC=CC2=C(OC(C)=O)C(CCCC)=C1
Molecular Formula
C17H20O3
Molecular Weight
272.34
References & Citations
[1]Summers JA, et al. Lipoxygenase inhibitory activity of U-66,858 and its deacetylated metabolite U-68,244 in human whole blood. Agents Actions. 1994 Mar;41 (1-2) :32-6.|[2]Johnson HG, et al. Activity of a novel hydroquinone inhibitor of leukotriene synthesis (U-66,858) in the rhesus monkey Ascaris reactor. Int Arch Allergy Appl Immunol. 1988;87 (2) :204-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; LTB4; TXB2
Available Sizes
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