Bunaprolast

Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.

Product Specifications

CAS Number

[99107-52-5]

Product Name Alternative

U66858

UNSPSC

12352005

Target

Leukotriene Receptor; Lipoxygenase; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/U66858.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C=CC=CC2=C(OC(C)=O)C(CCCC)=C1

Molecular Formula

C17H20O3

Molecular Weight

272.34

References & Citations

[1]Summers JA, et al. Lipoxygenase inhibitory activity of U-66,858 and its deacetylated metabolite U-68,244 in human whole blood. Agents Actions. 1994 Mar;41 (1-2) :32-6.|[2]Johnson HG, et al. Activity of a novel hydroquinone inhibitor of leukotriene synthesis (U-66,858) in the rhesus monkey Ascaris reactor. Int Arch Allergy Appl Immunol. 1988;87 (2) :204-7.