Guanoxabenz

Guanoxabenz is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3].

Product Specifications

CAS Number

[24047-25-4]

Product Name Alternative

Hydroxyguanabenz

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Guanoxabenz.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(/C=N/NC(NO)=N)C(Cl)=CC=C1

Molecular Formula

C8H8Cl2N4O

Molecular Weight

247.08

References & Citations

[1]Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmacol. 1998 Nov 1;56 (9) :1111-9.|[2]Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Biochem Pharmacol. 1998 Nov 1;56 (9) :1121-8.|[3]Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83 (4) :158-63.|[4]P W Dettmar, et al. Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Neuropharmacology. 1983 Jun;22 (6) :729-37.