Guanoxabenz
Guanoxabenz is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3].
Product Specifications
CAS Number
24047-25-4
Product Name Alternative
Hydroxyguanabenz
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Guanoxabenz.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(/C=N/NC(NO)=N)C(Cl)=CC=C1
Molecular Formula
C8H8Cl2N4O
Molecular Weight
247.08
References & Citations
[1]Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmacol. 1998 Nov 1;56 (9) :1111-9.|[2]Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1- (2,6-dichlorobenzylidene-amino) -3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Biochem Pharmacol. 1998 Nov 1;56 (9) :1121-8.|[3]Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83 (4) :158-63.|[4]P W Dettmar, et al. Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Neuropharmacology. 1983 Jun;22 (6) :729-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
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