Flosulide

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

Product Specifications

CAS Number

[80937-31-1]

Product Name Alternative

ZK 38997; CGP 28238

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Flosulide.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1OC3=CC=C(F)C=C3F)=O

Molecular Formula

C16H13F2NO4S

Molecular Weight

353.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Turull A, et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. Inflammation. 2001 Apr;25 (2) :119-28.|[2]Zimmermann KC, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59 (1) :198-204.|[3]Heise G, et al. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. Nephron. 1998 Oct;80 (2) :220-6.