NCX 1000
NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA) .
Product Specifications
CAS Number
401519-96-8
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/NCX_1000.html
Purity
96.19
Solubility
10 mM in DMSO
Smiles
C[C@H](CCC(OC1=CC=C(/C=C/C(OCCCCO[N+]([O-])=O)=O)C=C1OC)=O)[C@H]2CC[C@@]3([H])[C@]4([H])[C@@H](O)C[C@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C
Molecular Formula
C38H55NO10
Molecular Weight
685.84
References & Citations
[1]Fiorucci S, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A. 2001 Jul 17;98 (15) :8897-902. Epub 2001 Jul 10.|[2]Fiorucci S, et al. NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. J Hepatol. 2003 Dec;39 (6) :932-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
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