AVE-8134
Product Specifications
UNSPSC Description
AVE-8134 is a potent PPARα agonist, with EC50 values of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
Target Antigen
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/AVE-8134.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=C(COCCCOCC2=COC(C3=CC=CC=C3)=N2)C=CC=C1C
Molecular Weight
381.42
References & Citations
[1]Schafer HL, et al. AVE8134, a novel potent PPARα agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats. Acta Pharmacol Sin. 2012 Jan;33(1):82-90.|[2]Linz W, et al. The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats. Acta Pharmacol Sin. 2009 Jul;30(7):935-46.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-U00014/AVE-8134-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-U00014/
Clinical Information
Phase 2
CAS Number
304025-09-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9305771-01 48 Well
Human nicotinamide adenine dinucleotide phosphate/ II, NADPH/Co II /TPN ELISA Kit
Ask
View Details 
MBS9305771-02 96 Well
Human nicotinamide adenine dinucleotide phosphate/ II, NADPH/Co II /TPN ELISA Kit
Ask
View Details MBS9305771-03 5x 96 Well
Human nicotinamide adenine dinucleotide phosphate/ II, NADPH/Co II /TPN ELISA Kit
Ask
View Details 
MBS9305771-04 10x 96 Well
Human nicotinamide adenine dinucleotide phosphate/ II, NADPH/Co II /TPN ELISA Kit
Ask
View Details 