CAY10505
CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.
Product Specifications
CAS Number
1218777-13-9
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CAY10505.html
Purity
99.75
Solubility
DMSO : ≥ 34 mg/mL
Smiles
O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2
Molecular Formula
C14H8FNO3S
Molecular Weight
289.28
References & Citations
[1]Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8 (7) :e69019.|[2]Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166 (4) :529-39.|[3]Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90 (7), 881-5.|[4]Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11 (7) :500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ
Available Sizes
Frequently Asked Questions
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