CAY10505

CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.

Product Specifications

CAS Number

[1218777-13-9]

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CAY10505.html

Purity

99.75

Solubility

DMSO : ≥ 34 mg/mL

Smiles

O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2

Molecular Formula

C14H8FNO3S

Molecular Weight

289.28

References & Citations

[1]Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8 (7) :e69019.|[2]Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166 (4) :529-39.|[3]Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90 (7), 881-5.|[4]Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11 (7) :500.