ALX 40-4C
ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
Product Specifications
CAS Number
143413-49-4
UNSPSC
12352202
Target
Apelin Receptor (APJ) ; CXCR
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ALX_40-4C.html
Solubility
10 mM in H2O
Smiles
N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C56H113N37O10
Molecular Weight
1464.74
References & Citations
[1]Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17 (6) :475-86.|[2]Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59 (2) :137-42.|[3]Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312 (1) :196-203.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4
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