Chemerin-9 (149-157)
Product Specifications
UNSPSC Description
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1). Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].
Target Antigen
Akt; Amyloid-β; Chemerin Receptor; ERK; Reactive Oxygen Species
Type
Peptides
Related Pathways
GPCR/G Protein;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chemerin-9-149-157.html
Solubility
H2O
Smiles
OC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(N)=O)NC(CNC([C@H]3N(C([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)N)=O)=O)CCC3)=O)=O)=O)=O)=O)=O
Molecular Weight
1063.16
References & Citations
[1]Tu J, et, al. Regulatory effect of chemerin and therapeutic efficacy of chemerin 9 in pancreatogenic diabetes mellitus. Mol Med Rep. 2020 Mar;21(3):981-988.|[2]Chen S, et, al. Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE-/- Mice. J Oncol. 2021 Apr 17;2021:6629204.|[3]Lei Z, et, al. Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-Induced Object Memory Impairment in Mice. Biol Pharm Bull. 2020 Feb 1;43(2):272-283.|[4]Yamamoto A, et, al. Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. Eur J Pharmacol. 2021 Dec 5;912:174566.Hypertension. 2024 Feb 15.|Eur J Neurosci. 2024 Jul 23.|Eur J Pharmacol. 2022 Oct 25;175343.|MedComm. 2024 Aug 31.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1844/Chemerin-9-149-157-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1844/
Clinical Information
No Development Reported
CAS Number
676367-27-4
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