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Psalmotoxin 1

Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a) . Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease[1][3][4][6].

Product Specifications

CAS Number

880107-52-8

Product Name Alternative

PcTx1; Psalmopoeus cambridgei toxin-1

UNSPSC

12352209

Target

Apoptosis; Sodium Channel

Type

Peptides

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/psalmotoxin-1.html

Purity

99.02

Solubility

H2O

Smiles

O=C([C@@H](N)CCC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@@H](C)O)=O)CCCCN)=O)CCC5)=O)[C@@H](C)O)=O)CCCCN)=O)CCC4)=O)C(C)C)=O)=O)CC(O)=O)=O)=O)CC6=CNC=N6)=O)CCCNC(N)=N)=O)CC(N)=O)=O)C(C)C)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3C(C)C)=O)CCC(O)=O)=O)CC8=CC=CC=C8)=O)CO)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)=O)CCCCN)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCCCN)=O)CCC1)=O)[C@H](CC)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]7CCC(O)=O)=O)CC(C)C)=O)=O)CCC(O)=O)=O)=O)CC(O)=O

Molecular Formula

C200H312N62O57S6

Molecular Weight

4689.39

References & Citations

+

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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