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Cyclosporin A-Derivative 1 (Free base)

Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

Product Specifications

CAS Number

[286852-20-8]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Calcineurin; Cyclophilin

Type

Peptides

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Cyclosporin_A-Derivative_1_Free_base.html

Purity

98.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@](C(C)C)([H])N(C)C([C@H](CC(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N(C)C([C@@](C(C)C)([H])NC([C@H](CC(C)C)NC)=O)=O)=O)=O)=O)=O)=O)N(C)[C@]([C@H](OC(C)=O)[C@H](C)C/C=C/C)([H])C(N[C@@H](CC)C(N(C)CC(OC)=O)=O)=O

Molecular Formula

C65H117N11O14

Molecular Weight

1276.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Fabrice Gallou, et al. Process for the manufacture of cyclic undecapeptides. WO 2013167703 A1.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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