M40
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].
Product Specifications
CAS Number
143896-17-7
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/M40.html
Purity
71.08
Solubility
10 mM in H2O
Smiles
O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C95H146N22O24
Molecular Weight
1980.31
References & Citations
[1]Narváez JA, et al., The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15) . Eur J Pharmacol. 2000 Jul 7;399 (2-3) :197-203.|[2]McDonald MP, et al., Galanin inhibits performance on rodent memory tasks. Ann N Y Acad Sci. 1998 Dec 21;863:305-22. |[3]Branchek T, et al., Molecular biology and pharmacology of galanin receptors. Ann N Y Acad Sci. 1998 Dec 21;863:94-107.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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