N-Acetyl-Ser-Asp-Lys-Pro

N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

Product Specifications

CAS Number

[127103-11-1]

Product Name Alternative

Ac-SDKP

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/N-Acetyl-Ser-Asp-Lys-Pro.html

Solubility

10 mM in H2O

Smiles

O=C([C@@H](CC(O)=O)NC([C@H](CO)NC(C)=O)=O)N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(O)=O)=O

Molecular Formula

C20H33N5O9

Molecular Weight

487.50

References & Citations

[1]Rousseau A, et al. The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specificsubstrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem. 1995 Feb 24;270 (8) :3656-61.|[2]Pokharel S, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension. 2002 Aug;40 (2) :155-61.|[3]Rhaleb NE, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts. Pflugers Arch. 2013 Oct;465 (10) :1487-95.|[4]Rhaleb NE, et al. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice. J Hypertens. 2011 Feb;29 (2) :330-8.