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ATI-2341

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) [1][2].

Product Specifications

UNSPSC

12352209

Target

CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/ati-2341.html

Purity

99.64

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@@H](NC(CNC([C@H](CCSC)NC(CCCCCCCCCCCCCCC)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C104H178N26O25S2

Molecular Weight

2256.82

References & Citations

[1]Quoyer J, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24;110 (52) :E5088-97.|[2]Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107 (51) :22255-9.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P0172/ATI-2341-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P0172/ATI-2341-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

CXCR4

CAS Number

[1337878-62-2]

Available Sizes

Curated Selection

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