(Arg) 9 (TFA)

(Arg) 9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg) 9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].

Product Specifications

CAS Number

[2283335-13-5]

Product Name Alternative

Nona-L-arginine (TFA) ; Peptide R9 (TFA)

UNSPSC

12352209

Target

Ser/Thr Protease

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/arg-9-tfa.html

Purity

99.57

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(O)C(F)(F)F.N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C54H110N36O10.xC2HF3O2

Molecular Weight

1423.69 (free acid)

References & Citations

[1]Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34 (2) :173-81.|[2]Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35 (6) :993-1004.