Nifenalol (hydrochloride)

Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].

Product Specifications

CAS Number

[5704-60-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nifenalol-hydrochloride.html

Purity

99.93

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

OC(CNC(C)C)C1=CC=C([N+]([O-])=O)C=C1.[H]Cl

Molecular Formula

C11H17ClN2O3

Molecular Weight

260.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Lemmens-Gruber R, et al. Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331 (1) :46-58.