Nifenalol (hydrochloride)
Product Specifications
UNSPSC Description
Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nifenalol-hydrochloride.html
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
OC(CNC(C)C)C1=CC=C([N+]([O-])=O)C=C1.[H]Cl
Molecular Weight
260.72
References & Citations
[1]Lemmens-Gruber R, et al. Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331(1):46-58.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100952/Nifenalol-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100952/Nifenalol-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
5704-60-9
Available Sizes
Curated Selection
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