Cenisertib (benzoate)
Cenisertib (AS-703569) benzoate is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib benzoate induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC) . Cenisertib benzoate inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia[1][2][3].
Product Specifications
CAS Number
1145859-64-8
Product Name Alternative
AS-703569 (benzoate) ; R-763 (benzoate)
UNSPSC
12352005
Target
Akt; Aurora Kinase; Bcr-Abl; FLT3; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cenisertib-benzoate.html
Smiles
OC(C1=CC=CC=C1)=O.NC([C@H]2[C@@](C=C3)([H])C[C@@]3([H])[C@H]2NC4=NC(NC5=CC(C)=C(N6CCN(CC6)C)C=C5)=NC=C4F)=O
Molecular Formula
C31H36FN7O3
Molecular Weight
573.66
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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