Netropsin (dihydrochloride)

Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][4][5].

Product Specifications

CAS Number

[18133-22-7]

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/netropsin-dihydrochloride.html

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2.[H]Cl.[H]Cl

Molecular Formula

C18H28Cl2N10O3

Molecular Weight

503.39

Precautions

H301

References & Citations

[1]Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090 (1) :52-60.|[2]Grant MA, et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15;418 (1) :103-12.|[3]Mishra K et al. Netropsin, a minor groove binding ligand: a potential radioprotective agent. Radiat Res. 2009 Dec;172 (6) :698-705.|[4]Smee DF, et, al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.|[5]Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73 (1) : 341-343.