What is the catalog number for Nonactin?

The catalog number for Nonactin is HY-N6790.

What sizes are available for Nonactin?

Nonactin is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does Nonactin come in?

Nonactin is available in 2 different pack sizes.

Is Nonactin in stock?

Nonactin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Nonactin?

Nonactin is manufactured by QuantiMol.

What is the estimated delivery time for Nonactin?

Estimated delivery time for Nonactin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Nonactin?

The safety data sheet for Nonactin is available here: http://file.medchemexpress.com/batch_PDF/HY-N6790/Nonactin-SDS-MedChemExpress.pdf.

Nonactin

Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity[1][2][3][4].

Product Specifications

CAS Number

6833-84-7

Product Name Alternative

Ammonium ionophore I

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial; HSP; Influenza Virus; Mitochondrial Metabolism; Oxidative Phosphorylation; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nonactin.html

Purity

99.0

Solubility

DMF : 50 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 6.67 mg/mL (ultrasonic)

Smiles

O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O

Molecular Formula

C40H64O12

Molecular Weight

736.93

Precautions

H315, H319, H335

References & Citations

[1]Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19 (2) :1288-1297.|[2]Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108 (4) :772-784.|[3]Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62 (5) :1541-8.|[4]Boykova I, et al. Strain Streptomyces sp. P-56 Produces Nonactin and Possesses Insecticidal, Acaricidal, Antimicrobial and Plant Growth-Promoting Traits. Microorganisms. 2023 Mar 16;11 (3) :764.