4-Bromo A23187
4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells[1].
Product Specifications
CAS Number
76455-48-6
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Antibiotic; Apoptosis; Bacterial; Calcium Channel
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/4-bromo-a23187.html
Purity
99.0
Solubility
10 mM in DMSO|DMSO : ≥ 100mg/mL
Smiles
C[C@H]1[C@@]2(O[C@@H]([C@@H](CC2)C)CC3=NC4=C(C(O)=O)C(NC)=C(Br)C=C4O3)O[C@]([C@@H](C1)C)([H])[C@H](C)C(C5=CC=CN5)=O
Molecular Formula
C29H36BrN3O6
Molecular Weight
602.52
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Zhu WH, et al. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57 (23) :2091-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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