Isocryptotanshinone
Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation[1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC[1][3][4].
Product Specifications
CAS Number
[22550-15-8]
UNSPSC
12352005
Target
Akt; Apoptosis; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; CDK; EGFR; JAK; mTOR; p38 MAPK; PARP; Phosphatase; STAT; Survivin
Related Pathways
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1[C@H](C)CO4)=O
Molecular Formula
C19H20O3
Molecular Weight
296.36
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6651/Isocryptotanshinone-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
