Schinifoline

Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection[1][2].

Product Specifications

CAS Number

[80554-58-1]

UNSPSC

12352005

Hazard Statement

H300, H315, H319, H335

Target

Apoptosis; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/schinifoline.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(CCCCCCC)N(C)C2=C1C=CC=C2

Molecular Formula

C17H23NO

Molecular Weight

257.37

Precautions

H300, H315, H319, H335

References & Citations

[1]Wang CF, et al. Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation. Molecules. 2014 Dec 1;19 (12) :20128-38.|[2]Lu L, et al. Whole transcriptome analysis of schinifoline treatment in Caenorhabditis elegans infected with Candida albicans. Mol Immunol. 2021 Jul;135:312-319.