Uvarigrin
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation[1][2].
Product Specifications
CAS Number
[200563-11-7]
UNSPSC
12352005
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uvarigrin.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CCCCCCCCCCCC[C@H](O)C[C@H]([C@]2([H])O[C@]([C@H](O)CCCCCCCCCCCC)([H])CC2)O)=C[C@H](C)O1
Molecular Formula
C37H68O6
Molecular Weight
608.93
References & Citations
[1]Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62 (2) :261-4.|[2]Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41 (3) :252-6.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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