Uvarigrin

Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation[1][2].

Product Specifications

CAS Number

[200563-11-7]

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/uvarigrin.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CCCCCCCCCCCC[C@H](O)C[C@H]([C@]2([H])O[C@]([C@H](O)CCCCCCCCCCCC)([H])CC2)O)=C[C@H](C)O1

Molecular Formula

C37H68O6

Molecular Weight

608.93

References & Citations

[1]Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62 (2) :261-4.|[2]Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41 (3) :252-6.