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PROTAC SMARCA2/4-degrader-19

PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50 [1]

Product Specifications

CAS Number

2568277-57-4

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-19.html

Smiles

CC1=NC(N2C3CN(C4=C(N)N=NC(C5=C(C=CC=C5)O)=C4)CC2CC3)=NC=C1[C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O

Molecular Formula

C50H61N11O5S

Molecular Weight

928.16

References & Citations

[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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