13-Oxyingenol-13-dodecanoate
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM[1].13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis[2].
Product Specifications
CAS Number
54706-70-6
UNSPSC
12352211
Target
Bcl-2 Family; HIV; ULK
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Dodecanoic-acid-ingenol-ester.html
Purity
99.37
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCC(O[C@@]12C[C@@H](C)[C@@](C=C(C)[C@@H]3O)(C4=O)[C@]3(O)[C@H](O)C(CO)=C[C@@]4([H])[C@]1([H])C2(C)C)=O
Molecular Formula
C32H50O7
Molecular Weight
546.74
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Frequently Asked Questions
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