Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His, Avitag™&Tag Free (MALS verified)
Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Product Specifications
Background
Specifications
Accession Number
NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)
Expression Region
Phe 31 - Val 992 (ITGAV) & Gly 22 - Asn 707 (ITGB6)
Host
HEK293
Target
Integrin alpha V beta 6
Conjugation
Biotin-labeled
Tag
C-10xHis & C-Avi | Native
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
114.7 kDa (ITGAV) & 79.6 kDa (ITGB6)
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
200ug*1
Host or Source
HEK293
Species
Human
Protein ID
NP_002201.1 (ITGAV) & AAI21179.1 (ITGB6)
Preservative
Trehalose
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