Phytic acid (50% in water)

Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research[1][2][3][4][5][6][7][8][9][10].

Product Specifications

CAS Number

[83-86-3]

Product Name Alternative

Inositol hexaphosphate; SNF472 (free acid)

UNSPSC

12352211

Hazard Statement

H314

Target

Amyloid-β; Autophagy; Endogenous Metabolite

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Phytic_acid.html

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 30 mg/mL

Smiles

O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O

Molecular Formula

C6H18O24P6

Molecular Weight

660.04

Precautions

H314

References & Citations

[1]Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13 (3) :151-8.|[2]Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82 (4) :1040-1049.|[3]Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8.|[4]Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90 (2) :543-9.|[5]Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23 (1) :21-35.|[6]Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58 (3) :2028-33. |[7]Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4. |[8]Xu Z, et al. Protective effects of phytic acid on CCl4‐induced liver fibrosis in mice. Journal of Food Biochemistry, 2023, 2023 (1) : 6634450.|[9]Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494.|[10]Verghese M, et al. Anticarcinogenic effect of phytic acid (IP6) : apoptosis as a possible mechanism of action. LWT-Food Science and Technology, 2006, 39 (10) : 1093-1098.