Jatrorrhizine
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
Product Specifications
CAS Number
3621-38-3
UNSPSC
12352005
Hazard Statement
H302-H319-H332-H372-H400
Target
5-HT Receptor; Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jatrorrhizine.html
Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1
Molecular Formula
C20H20NO4+
Molecular Weight
338.38
Precautions
P260-P261-P264-P270-P271-P273-P280-P304+P340-P305+P351+P338-P330-P391-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Citation 01
Arch Microbiol. 2025 Jun 17;207 (8) :177.|Molecules. 2024 May 14.
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