Jatrorrhizine
Product Specifications
UNSPSC Description
Jatrorrhizine is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
Target Antigen
5-HT Receptor; Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection;GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jatrorrhizine.html
Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1
Molecular Weight
338.38
References & Citations
[1] Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.|[2]Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017|[3]C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0749/Jatrorrhizine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0749/
Clinical Information
No Development Reported
CAS Number
3621-38-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
LAC534Hu71-01 100 µL
Biotin-Linked Polyclonal Antibody to Histidine Rich Glycoprotein (HRG)
Ask
View Details LAC534Hu71-02 200 µL
Biotin-Linked Polyclonal Antibody to Histidine Rich Glycoprotein (HRG)
Ask
View Details