Dicoumarol
Dicoumarol is an inhibitor of both NAD (P) H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.
Product Specifications
CAS Number
66-76-2
Product Name Alternative
Dicumarol
UNSPSC
12352005
Hazard Statement
H301, H372, H401, H411
Target
PDHK; Quinone Reductase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dicoumarol.html
Purity
99.89
Solubility
DMSO : 3.67 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; adjust pH to 11 with NaOH)
Smiles
O=C1C(CC2=C(C3=CC=CC=C3OC2=O)O)=C(C4=CC=CC=C4O1)O
Molecular Formula
C19H12O6
Molecular Weight
336.29
Precautions
H301, H372, H401, H411
References & Citations
[1]Bian J, et al. Affinity-based small fluorescent probe for NAD (P) H:quinone oxidoreductase 1 (NQO1) . Design, synthesis and pharmacological evaluation. Eur J Med Chem. 2017 Feb 15;127:828-839.|[2]Zhang W, et al. Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. PLoS One. 2017 Jun 15;12 (6) :e0179672.|[3]Fiorillo M, et al. Mitochondrial "power" drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer. Oncotarget. 2017 Mar 2;8 (12) :20309-20327.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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