IM156

IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy depletion in tumor cells by inhibiting oxidative phosphorylation. IM156 at a concentration of 15 μM in combination with temozolomide decreases the stemness and invasive properties of glioblastoma tumorspheres. IM156 is in phase I clinical trials for advanced solid tumors and lymphoma.