What is the catalog number for Phellodendrine?

The catalog number for Phellodendrine is HY-N0427.

What sizes are available for Phellodendrine?

Phellodendrine is available in the following size(s): 1 Each.

Is Phellodendrine in stock?

Phellodendrine is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Phellodendrine?

Phellodendrine is manufactured by QuantiMol.

What is the estimated delivery time for Phellodendrine?

Estimated delivery time for Phellodendrine is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Phellodendrine?

The safety data sheet for Phellodendrine is available here: http://file.medchemexpress.com/batch_PDF/HY-N0427/Phellodendrine-SDS-MedChemExpress.pdf.

Phellodendrine

Phellodendrine is an orally active plant alkaloid. Phellodendrine inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway[1][2][3][4][5][6].

Product Specifications

CAS Number

6873-13-8

UNSPSC

12352005

Target

Akt; AMPK; Apoptosis; Autophagy; COX; Interleukin Related; MMP; mTOR; NF-κB; p38 MAPK; PI3K; PKC; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phellodendrine.html

Purity

99.60

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C2CC[N@@+]3(C)CC4=CC(OC)=C(O)C=C4C[C@@]3([H])C2=C1

Molecular Formula

C20H24NO4

Molecular Weight

342.41

References & Citations

[1]Li L , et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Life Sci. 2016 Jul 15;157:97-106.|[2]Qin YY, et al. Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway. Immunobiology. 2025 Jul;230 (4) :152918.|[3]Wang J, et al. Inhibitory effect of phellodendrine on C48/80-induced allergic reaction in vitro and in vivo. Int Immunopharmacol. 2024 Jun 15;134:112256.|[4]Hu L, et al. Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression. Sci Rep. 2025 Jan 14;15 (1) :1958.|[5]Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.|[6]Su S, Wang X, Xi X, et al. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021;25 (12) :5707-5720.