(+) -Magnoflorine

(+) -Magnoflorine (α-Magnoflorine) is an aporphine alkaloid and antifungal agent. (+) -Magnoflorine can be isolated from the aerial parts of Clematis parviloba. (+) -Magnoflorine shows potent antifungal activities against Penicillium avellaneum UC-4376 with a minimal inhibition amount of 5 μg/disc. (+) -Magnoflorine has significant antifungal activities against T. rubrum and T. mentagrophyte with MIC values of 62.5 μg/mL and 62.5 μg/mL, respectively[1][2].

Product Specifications

CAS Number

[2141-09-5]

Product Name Alternative

Magnoflorine; α-Magnoflorine; Thalictrine

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/magnoflorine.html

Solubility

10 mM in DMSO

Smiles

C[N+]1(C)CCC2=CC(OC)=C(O)C3=C2[C@]1([H])CC4=CC=C(OC)C(O)=C34

Molecular Formula

C20H24NO4+

Molecular Weight

342.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Chen JH, et al. Aporphine alkaloids from Clematis parviloba and their antifungal activity. Arch Pharm Res. 2009 Jan;32 (1) :3-5. |[2]Luo N, et al. Antifungal activity and potential mechanism of magnoflorine against Trichophyton rubrum. J Antibiot (Tokyo) . 2021 Mar;74 (3) :206-214.