Tacrine (hydrochloride) (hydrate)
Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
Product Specifications
CAS Number
[206658-92-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tacrine_hydrochloride_hydrate.html
Purity
99.98
Solubility
DMSO : 32 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)
Smiles
NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl.[H]O[H].[x].[x]
Molecular Formula
C13H14N2.xHCl.xH2O
Precautions
H302, H315, H319, H335
References & Citations
[1]Ahmed M, et al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162 (2) :165-71.|[2]Grasing K, et al. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE; BChE
Citation 01
Drug Deliv. 2025 Dec 31;32 (1) :2585612.|Front Neurosci. 2020 May 28:14:458.|J Neurochem. 2025 Aug;169 (8) :e70178.|Bioorg Chem. 2024 Feb:143:107010.|Cell Death Dis. 2022 Jan 10;13 (1) :48.|Eur J Med Chem. 2024 Feb 5:265:116071.|J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2192439.|J Med Chem. 2025 Nov 27;68 (22) :24326-24357.
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