7-Aminocephalosporanic acid
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor[1][2].
Product Specifications
CAS Number
957-68-6
Product Name Alternative
7-ACA
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/7-Aminocephalosporanic-acid.html
Purity
99.15
Solubility
H2O : 1.1 mg/mL (ultrasonic; adjust pH to 14 with NaOH)
Smiles
O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](N)C1=O)O
Molecular Formula
C10H12N2O5S
Molecular Weight
272.28
Precautions
H317, H334
References & Citations
[1]Ding JM, et al. Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis. J Bacteriol. 2015 Nov 2;198 (2) :311-20.|[2]Zhang W, et al. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis. Biochem Biophys Res Commun. 2022 Sep 24;622:184-191.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β-lactam
Available Sizes
Frequently Asked Questions
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